Thermo Fisher Scientific COMMD1 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.

Target Information

COMMD1 is a proposed scaffold protein involved in diverse physiological processes, particularly in regulating ubiquitination of cellular proteins. It modulates the activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, promoting CRL E3 activity, and facilitating ubiquitination of NF-κB subunit RELA, leading to its proteasomal degradation and down-regulation of NF-κB activity.

COMMD1 also regulates:

• Membrane expression and ubiquitination of SLC12A2
• Sodium transport in epithelial cells via ENaC subunit regulation
• CFTR surface expression through ubiquitination control
• SOD1 activity by interfering with homodimerization
• Copper ion homeostasis and ATP7A trafficking
• HIF1A-mediated transcription through competitive binding with ARNT/HIF-1β

COMMD1 binds one copper ion per monomer and may facilitate biliary copper excretion within hepatocytes. It also interacts with phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.