Thermo Fisher Scientific COMMD1 Polyclonal Antibody
Rabbit polyclonal antibody against human COMMD1, validated for ICC/IF. Affinity-purified with >95% purity. Suitable for human, mouse, and rat samples. Supplied in PBS with 50% glycerol, 1 mg/mL concentration. For research use only.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human COMMD1 (amino acids 1–190) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720880 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
COMMD1 is a proposed scaffold protein involved in diverse physiological processes, particularly in regulating ubiquitination of cellular proteins. It modulates the activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, promoting CRL E3 activity, and facilitating ubiquitination of NF-κB subunit RELA, leading to its proteasomal degradation and down-regulation of NF-κB activity.
COMMD1 also regulates:
- Membrane expression and ubiquitination of SLC12A2
- Sodium transport in epithelial cells via ENaC subunit regulation
- CFTR surface expression through ubiquitination control
- SOD1 activity by interfering with homodimerization
- Copper ion homeostasis and ATP7A trafficking
- HIF1A-mediated transcription through competitive binding with ARNT/HIF-1β
COMMD1 binds one copper ion per monomer and may facilitate biliary copper excretion within hepatocytes. It also interacts with phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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