Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI1H10), TrueMAB
Beta-catenin 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P) 검증 완료. Human 및 Mouse 시료에 반응하며, 1 mg/mL 농도의 동결건조 형태로 제공. 세포 접착 및 신호전달 연구에 적합. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H10 |
| Immunogen | Full length human recombinant protein of human CTNNB1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance.
It interacts with E-cadherin and alpha-catenin to link adhesion complexes to the actin cytoskeleton.
Beta-catenin also associates with cytoskeletal complexes containing the adenomatous polyposis coli (APC) protein and participates in signaling pathways such as Wnt/Wingless.
It plays a key role in morphogenesis and is expressed in hair follicle cells and epithelial tissues.
Aberrant beta-catenin activity is implicated in several cancers including colorectal, ovarian, and liver cancers.
In the nucleus, beta-catenin coactivates Lef/Tcf transcription factors that promote genes like cyclin D and c-myc, driving cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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