Thermo Fisher Scientific Phospho-VANGL2 (Thr78, Ser79) Recombinant Rabbit Monoclonal Antibody (5K4D6)
인간 VANGL2 단백질의 Thr78, Ser79 인산화 부위를 인식하는 재조합 토끼 단클론 항체. Western blot 및 ELISA에 적합하며, 1 mg/mL 농도의 액상 형태로 제공. 세포막 단백질 연구 및 신호전달 경로 분석에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5K4D6 |
| Immunogen | A phospho-specific peptide corresponding to residues surrounding T78/S79 of human VANGL2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 50% glycerol, 0.05% BSA |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2912099 |
Product Specific Information
The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.
Target Information
Van Gogh (VANGL2) is a vertebrate homolog of the Drosophila strabismus protein and a component of the frizzled-disheveled tissue polarity pathway.
VANGL2 interacts with DVL1, DVL2, and DVL3 through its C-terminal region and functions as a tumor suppressor.
It plays a critical role in early morphogenesis, axial patterning, and planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea.
VANGL2 is also required for polarization and movement of myocardializing cells, acting via RHOA signaling.
It is expressed in a wide range of tissues.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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