Thermo Fisher Scientific Carcinoembryonic Antigen (CEA)/CD66 Recombinant Rabbit Monoclonal Antibody (C66, 1983R)
Recombinant rabbit monoclonal antibody specific to human CEA/CD66 (clone C66, 1983R). Optimized for IHC (P) applications. High purity (Protein A/G), liquid form, 200 µg/mL concentration. Useful for identifying adenocarcinoma origin and tumor marker stu...
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | C66, 1983R |
| Immunogen | Recombinant full-length human CEA protein (CD66e, CEACAM5, UniProt ID: P06731-1, 1–702 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For IHC (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
CEA (Carcinoembryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors. It belongs to the immunoglobulin supergene family, comprising one N domain and six constant-like A and B domains.
Antibodies to CEA help identify metastatic adenocarcinomas and distinguish pulmonary adenocarcinomas (CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
CEA functions as a cell adhesion molecule found on leukocytes, epithelia, and endothelia, mediating homophilic and heterophilic interactions. It plays roles in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation.
Multiple transcript variants exist, though not all full-length forms have been defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: 1048-RBM13-P0_CD66e_CEACAM5_P06731-1_Rabbit_PDP.jpeg)
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