Thermo Fisher Scientific Carcinoembryonic Antigen (CEA)/CD66 Recombinant Rabbit Monoclonal Antibody (C66, 2055R)

Thermo Fisher Scientific Carcinoembryonic Antigen (CEA)/CD66 Recombinant Rabbit Monoclonal Antibody (C66, 2055R)

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.

Target Information

CEA (Carcinoembryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors. It belongs to the immunoglobulin supergene family, comprising one N domain and six immunoglobulin constant-like A and B domains.
Antibodies to CEA are useful for identifying the origin of metastatic adenocarcinomas and distinguishing pulmonary adenocarcinomas (60–70% CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
CEA functions as a cell-cell adhesion molecule and plays roles in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune response modulation. Multiple transcript variants encoding different isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: 1048-RBM15-P0_CD66e_CEACAM5_P06731-1_Rabbit.svg, 1048-RBM15-P0_CD66e_CEACAM5_P06731-1_Rabbit_PDP.jpeg)