Thermo Fisher Scientific TMEM43 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TMEM43. Recombinant protein control fragment (Product #RP-91179). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TMEM43,uniProtId:Q9BTV4-1,ncbiNodeId:9606,antigenRange:203-308,antigenLength:400,antigenImageFileName:PA5-53952_TMEM43_Q9BTV4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53952_TMEM43_Q9BTV4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648699

Product Specific Information

Immunogen sequence: FKSLSLSKLE DPHVDIIRRG DFFYHSENPK YPEVGDLRVS FSYAGLSGDD PDLGPAHVVT VIARQRGDQL VPFSTKSGDT LLLLHHGDFS AEEVFHRELR SNSMKT

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

Target Information

This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.