Thermo Fisher Scientific HCN1 Polyclonal Antibody
HCN1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, Flow Cytometry에 사용 가능. 인간 시료 반응성, 항원 친화 크로마토그래피 정제, 0.4 mg/mL 농도. 연구용으로 심장 및 뇌 리듬 조절 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | – |
| Flow Cytometry (Flow) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HCN1. Recombinant protein control fragment (Product #RP-91018). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642337 |
Product Specific Information
Immunogen sequence:
PSLPHEVSTL ISRPHPTVGE SLASIPQPVT AVPGTGLQAG GRSTVPQRVT LFRQMSSGAI PPNRGVPPAP PPPAAALPRE SSSVLNTDPD AE
Highest antigen sequence identity to orthologs:
- Mouse: 91%
- Rat: 87%
Target Information
HCN1 (Hyperpolarization-activated cation channel 1) is part of the HCN gene family contributing to rhythmic activity in heart and brain.
HCN1 channels are activated by hyperpolarization and regulated by cyclic nucleotides. They play key roles in motor learning, neuronal integration, and autonomous neuronal activity.
Expression is enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus.
HCN2 is abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body.
Regional specificity of HCN channels may lead to differences in neuronal pacemaker activity across brain systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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