Thermo Fisher Scientific BLVRA Monoclonal Antibody (S2)
Thermo Fisher Scientific의 BLVRA Monoclonal Antibody (S2)는 인간 BLVRA 단백질을 인식하는 Mouse IgG1 항체로, WB, ELISA, IP에 적합합니다. 고순도 친화 크로마토그래피로 정제되었으며 PBS buffer에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 3 ng/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S2 |
| Immunogen | BLVRA (AAH08456, 1–296 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MNAEPERKFG VVVVGVGRAG SVRMRDLRNP HPSSAFLNLI GFVSRRELGS IDGVQQISLE DALSSQEVEV AYICSESSSH EDYIRQFLNA GKHVLVEYPM TLSLAAAQEL WELAEQKGKV LHEEHVELLM EEFAFLKKEV VGKDLLKGSL LFTAGPLEEE RFGFPAFSGI SRLTWLVSLF GELSLVSATL EERKEDQYMK MTVCLETEKK SPLSWIEEKG PGLKRNRYLS FHFKSGSLEN VPNVGVNKNI FLKDQNIFVQ KLLGQFSEKE LAAEKKRILH CLGLAEEIQK YCCSRK
Target Information
Biliverdin reductase (BLVR) is a small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. This process begins with heme oxygenase converting heme to iron, carbon monoxide, and biliverdin. BLVR is unique in being dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as electron donors.
There are two isoforms:
- BLVRA (biliverdin-IX alpha-reductase): Major component of human adult liver
- BLVRB (biliverdin-IX beta-reductase): Found predominantly in fetal liver
Bilirubin, the product of BLVR activity, acts as a biological antioxidant but can also be neurotoxic, causing kernicterus. It additionally inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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