Thermo Fisher Scientific MMAF Monoclonal Antibody (A5G11)
Thermo Fisher Scientific의 MMAF Monoclonal Antibody (A5G11)는 MMAF-OVA 면역원으로 제작된 Mouse IgG1 단일클론 항체입니다. ELISA에 최적화되어 있으며, 2 mg/mL 농도의 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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- MA542538
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카탈로그
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Applications
Tested Dilution
- ELISA: 1:5,000–1:20,000
Publications
- [참고 문헌 정보 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chemical |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A5G11 |
| Immunogen | MMAF coupled with OVA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911679 |
Product Specific Information
- Product has been tested in direct ELISA.
Target Information
Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of the approved drug belantamab mafodotin used in multiple myeloma and in experimental antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.
In International Nonproprietary Names for MMAF-antibody-conjugates, mafodotin refers to MMAF plus its attachment structure to the antibody.
MMAF is an antimitotic agent that inhibits cell division by blocking tubulin polymerization. When conjugated with an antibody targeting cancer cell structures, MMAF accumulates selectively in those cells.
Chemically, MMAF is desmethyl-auristatin F, meaning the N-terminal amino group has one methyl substituent instead of two as in auristatin F.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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