Thermo Fisher Scientific TRPM5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Glycerol (1:1) may be added for additional stability.
• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.

Target Information

This gene encodes a member of the transient receptor potential protein family, a diverse group of proteins with structural features typical of ion channels.
TRPM5 plays an important role in taste transduction and functions as a calcium-activated, non-selective cation channel that conducts Na⁺, K⁺, and Cs⁺ ions but not Ca²⁺ ions.
It is activated by lower concentrations of intracellular Ca²⁺ and inhibited by higher concentrations.
Additionally, it is a temperature-sensitive, heat-activated channel showing a steep increase of inward currents between 15°C and 35°C.
The gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5 and is imprinted, expressed exclusively from the paternal allele.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.