Thermo Fisher Scientific CRY2 Polyclonal Antibody
CRY2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P)에서 검증됨. 인간 및 생쥐 시료에 반응하며 고순도 정제. 단기 4°C, 장기 -20°C 보관 가능. 생체 리듬 관련 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 564–593 of the C-terminal region of human CRY2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% Sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2083988 |
Target Information
Circadian rhythms regulate various biochemical, physiological, and behavioral processes through an internal biological clock. The central mechanism involves an autoregulatory transcriptional and post-translational feedback loop. Cryptochrome 1 (CRY1) and Cryptochrome 2 (CRY2) are DNA-binding flavoproteins homologous to blue-light receptors and photolyases.
In Drosophila, CRY acts as a photoreceptor that binds to TIM in a light-dependent manner to modulate circadian rhythm. In mammals, CRY1 and CRY2 interact with CLOCK, BMAL1, PER1, PER2, and TIM in a light-independent fashion, regulating circadian gene expression. Mutant mice lacking Cry1 or Cry2 show altered locomotor activity cycles, and double mutants lose rhythmicity entirely, indicating the essential role of CRY proteins in maintaining circadian synchronization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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