Thermo Fisher Scientific CRY1 Polyclonal Antibody
CRY1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 IHC(P)에서 검증됨. 인간 및 설치류 반응성. KLH 결합 합성 펩타이드 면역원 사용. 고순도, 액상 형태로 제공되며 연구용으로 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between amino acids 556–586 from the C-terminal region of human Cry1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.8 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2083983 |
Product Specific Information
This antibody is predicted to react with non-human primates based on sequence homology.
Target Information
Various biochemical, physiological, and behavioral processes display circadian rhythms controlled by an internal biological clock. The central mechanisms driving this clock are composed of an autoregulatory transcription/post-translation feedback loop.
Cryptochrome 1 (CRY1) and Cryptochrome 2 (CRY2) are DNA-binding flavoproteins homologous to blue-light receptors and photolyases. In Drosophila, CRY acts as a photoreceptor for the circadian clock, binding to the TIM component in a light-dependent manner. Mammalian CRY1 and CRY2 interact with CLOCK, BMAL1, PER1, PER2, and TIM genes in a light-independent fashion, regulating circadian rhythms.
Mutant mice lacking Cry1 or Cry2 show altered locomotor activity periodicity, indicating that both proteins are essential for synchronization of circadian phases. Double-mutant mice exhibit arrhythmicity in complete darkness, demonstrating the absence of an internal circadian clock.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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