Thermo Fisher Scientific CACTIN Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CACTIN. Recombinant protein control fragment (Product #RP-98977). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CACTIN,uniProtId:Q8WUQ7-1,ncbiNodeId:9606,antigenRange:550-629,antigenLength:758,antigenImageFileName:PA5-60019_CACTIN_Q8WUQ7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60019_CACTIN_Q8WUQ7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639219

Product Specific Information

Immunogen sequence: SLDDYDAGRY SPRLLTAHEL PLDAHVLEPD EDLQRLQLSR QQLQVTGDAS ESAEDIFFRR AKEGMGQDEA QFSVEMPLTG

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

Target Information

Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidences show overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported Cactin interacts with IkB-like protein and targets other proteins that are encoded by genes in the MHC Class III region of chromosome 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.