Thermo Fisher Scientific CACTIN Polyclonal Antibody
Human CACTIN 단백질에 특이적인 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공. TLR 신호 억제 연구 및 MHC Class III 관련 단백질 분석에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CACTIN. Recombinant protein control fragment (Product #RP-98977). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639219 |
Product Specific Information
Immunogen sequence:
SLDDYDAGRY SPRLLTAHEL PLDAHVLEPD EDLQRLQLSR QQLQVTGDAS ESAEDIFFRR AKEGMGQDEA QFSVEMPLTG
Highest antigen sequence identity to the following orthologs:
- Mouse: 94%
- Rat: 94%
Target Information
Cactin is a novel negative regulator of TLR signaling and reveals its capacity to target MHC Class III genes at the molecular and functional level. It is localized to the nucleus, which is critical for manifesting its inhibitory effects on TLR signaling. Experimental evidence shows that overexpression of Cactin suppresses TLR-induced activation of NF-kB and interferon-regulatory factor transcription factors and induction of TLR-responsive genes. It is also reported that Cactin interacts with IkB-like protein and targets other proteins encoded by genes in the MHC Class III region of chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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