Thermo Fisher Scientific GRID2 Polyclonal Antibody
GRID2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC 및 ICC/IF에 사용 가능하며, 인간·마우스·랫트 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제, 1 mg/mL 농도, 장기보관 -20°C.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 831–880 of human GluR-delta2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553509 |
Product Specific Information
This antibody detects endogenous GRID2 protein at a molecular weight of 113 kDa.
Purity is >95% by SDS-PAGE.
Target Information
GRID2 is a member of the family of ionotropic glutamate receptors, which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein expressed selectively in cerebellar Purkinje cells.
A point mutation in the mouse ortholog, known as lurcher, leads to ataxia due to selective apoptosis of Purkinje cells during postnatal development. Homozygous mice die shortly after birth from massive neuronal loss. GRID2 also plays a role in synapse organization between parallel fibers and Purkinje cells.
Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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