Thermo Fisher Scientific GLRX2 Polyclonal Antibody
인간 GLRX2 단백질을 인식하는 토끼 폴리클로나 항체로, Western blot 및 ELISA에 적합. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 미토콘드리아 및 핵 내 단백질 검출에 유용. 연구용으로만 사용.
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- PA593087
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Thermo Fisher Scientific GLRX2 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–124 of human GLRX2 (NP_001230328.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.14 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806616 |
Product Specific Information
- Immunogen sequence: MESNTSSSLE NLATAPVNQI QETISDNCVV IFSKTSCSYC TMAKKLFHDM NVNYKVVELD LLEYGNQFQD ALYKMTGERT VPRIFVNGTF IGGATDTHRL HKEGKLLPLV HQCYLKKSKR KEFQ
- Positive Samples: MCF7
- Cellular Location: Mitochondrion, Nucleus
Target Information
Glutaredoxin (Grx), also known as thiol transferase, is a small heat-stable oxidoreductase. Grxs are part of the glutaredoxin system, which includes NADPH, GSH, and glutathione reductase, transferring electrons from NADPH to glutaredoxins via GSH. Originally discovered in E. coli as GSH-dependent hydrogen donors for ribonucleotide reductase, Grx catalyzes GSH-disulfide oxidoreductase reactions via two redox-active cysteine residues. The active sequence (Cys-Pro-Tyr-Cys) is conserved across species. This 12-kDa dithiol protein plays a key role in reducing mixed disulfides in cells under oxidative stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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