Thermo Fisher Scientific CD45 Monoclonal Antibody (UM16-6)
닭 CD45 단백질을 인식하는 UM16-6 클론의 마우스 단클론 항체입니다. IHC(F), Flow Cytometry, Immunoprecipitation에 사용 가능합니다. 단백질 G로 정제된 액상 항체로, 1 mg/mL 농도이며 4°C 또는 -20°C에서 보관합니다. 연구용으로만 사용됩니다.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1:100–1:200 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UM16-6 |
| Immunogen | COS cells transfected with CD45 gene |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745347 |
Additional Formats
Product Specific Information
Mouse anti-Chicken CD45 antibody, clone UM16-6 recognizes chicken CD45, also known as leukocyte common antigen.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising about 10% of surface proteins in lymphocytes. It is absent on non-hematopoietic cells and tissues. CD45 glycoprotein plays a crucial role in lymphocyte development and antigen signaling by regulating Src-family kinases.
CD45 exists in multiple isoforms due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic regions. CD45RA is one isoform with restricted expression among lymphoid subtypes. Isoform expression and localization depend on cell type and physiological state. CD45 regulates T- and B-cell receptor signaling, modulates cytokine receptor pathways via JAK kinases, and influences cell survival, integrin-mediated signaling, and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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