Thermo Fisher Scientific CD45 Monoclonal Antibody (VPM18)
Thermo Fisher Scientific의 CD45 Monoclonal Antibody (VPM18)는 양 CD45 항원을 인식하는 마우스 IgG1 단클론 항체로, IHC, Flow Cytometry, IP에 사용 가능. 단백질 G로 정제된 액상 형태이며, PBS 버퍼와 sodium azide를 포함. 연구용으로만 사용.
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Applications
- Immunohistochemistry (Frozen) (IHC (F)): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Sheep |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VPM18 |
| Immunogen | Sheep T lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745348 |
Product Specific Information
Mouse anti-Sheep CD45, clone VPM18 recognizes the ovine homologue of human CD45, also known as LCA (leucocyte common antigen). CD45 is a type I transmembrane glycoprotein and member of the protein-tyrosine phosphatase (PTP) family, expressed at high levels on all nucleated cells of hematopoietic origin. It exists in several isoforms generated by alternative splicing.
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed ubiquitously in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. It is absent on non-hematopoietic cell lines and tissues. CD45 glycoprotein plays a crucial role in lymphocyte development and antigen signaling, regulating Src-family kinases and JAK kinases. It also modulates integrin-mediated signaling, apoptosis, and other immunological functions. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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