Thermo Fisher Scientific Neuronal-Nuclei (NeuN) (Neuronal Marker) Recombinant Rabbit Monoclonal Antibody (NeuN/288R)
신경세포 마커 NeuN을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 면역조직화학(IHC)에 사용 가능. 인간 및 생쥐 시료에 반응하며, 단백질 A/G로 정제된 액상 형태. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | NeuN/288R |
| Immunogen | Recombinant full-length human NeuN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Fox-3, also known as NEUN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain. It is localized to both the nucleus and cytoplasm and is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which constitutes over 2.5% of the human genome and encodes more than 1,200 genes.
Two key tumor suppressor genes, p53 and BRCA1, are associated with chromosome 17. p53 maintains genetic integrity by moderating cell fate through DNA repair versus apoptosis, while BRCA1 is involved in DNA repair and is a known determinant of early-onset breast and ovarian cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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