Thermo Fisher Scientific Neuronal-Nuclei (NeuN) (Neuronal Marker) Recombinant Rabbit Monoclonal Antibody (NeuN/7071R)
NeuN/7071R 항체는 인간 신경세포 핵 단백질 NeuN을 특이적으로 인식하는 재조합 토끼 단일클론 항체입니다. IHC(P) 및 IHC(PFA) 실험에 적합하며, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | NeuN/7071R |
| Immunogen | A synthetic peptide corresponding to residues within aa 30–60 of human NeuN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Fox-3, also known as NeuN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain. It is localized to both the nucleus and cytoplasm and is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes more than 1,200 genes. Two key tumor suppressor genes associated with chromosome 17 are p53 and BRCA1:
- p53: Maintains genetic integrity through DNA repair and cell fate moderation; malfunction or loss is linked to malignant growth and Li-Fraumeni syndrome.
- BRCA1: Involved in DNA repair and recognized as a determinant of early onset breast cancer and predisposition to several other cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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