Thermo Fisher Scientific CBF-beta (isoform 1) Polyclonal Antibody
CBF-beta 단백질의 isoform 1을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 Immunoprecipitation에 적합합니다. Human 및 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- A303549A
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 166 and 187 of human Core-Binding Factor, Beta Subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family, which master-regulates genes involved in hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2).
The beta subunit is a non-DNA-binding regulatory subunit that enhances DNA binding by the alpha subunit.
Alternative splicing generates two mRNA variants encoding distinct isoforms.
A pericentric inversion of chromosome 16 [inv(16)(p13q22)] can produce a chimeric transcript associated with acute myeloid leukemia (M4Eo subtype).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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