Thermo Fisher Scientific CBF-beta (isoform 1) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family, which regulates genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2).
The beta subunit is a non-DNA-binding regulatory unit that enhances DNA binding by the alpha subunit as the complex binds to enhancer and promoter regions such as murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, and GM-CSF promoters.
Alternative splicing generates two mRNA variants encoding distinct carboxyl termini. A pericentric inversion of chromosome 16 [inv(16)(p13q22)] can produce a chimeric transcript combining the N terminus of CBF-beta with the C-terminal portion of smooth muscle myosin heavy chain 11, associated with acute myeloid leukemia (M4Eo subtype). Two transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.