Thermo Fisher Scientific TET2 Polyclonal Antibody
Human TET2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 PBS 용액 형태. DNA 탈메틸화 연구 및 TET2 관련 질환 연구에 적합.
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Thermo Fisher Scientific TET2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 18 amino acid synthetic peptide near the amino terminus of human TET2 (amino acids 20–70) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term; for long-term storage, store at -20°C (avoid freeze/thaw cycles) |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890357 |
Product Specific Information
Positive control recommended: SK-N-SH Cell Lysate
Target Information
TET2 is a dioxygenase that catalyzes the conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), playing a key role in active DNA demethylation. It further mediates conversion of 5hmC to 5-formylcytosine (5fC) and 5fC to 5-carboxylcytosine (5caC), constituting initial steps of cytosine demethylation.
Additionally, TET2 recruits O-GlcNAc transferase (OGT) to CpG-rich transcription start sites, promoting histone H2B GlcNAcylation.
Mutations in TET2 are associated with Polycythemia vera and Myelodysplastic syndrome.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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