Thermo Fisher Scientific Blood Group H Antigen Monoclonal Antibody (86-N)

Applications

• Agglutination (AGG)

Tested Dilution: 1:50
Publications: -

Product Specifications

Product Specific Information

MA1-7673 detects H1 and H2 human blood from human samples.
MA1-7673 has been successfully used in agglutination applications.
The MA1-7673 immunogen is a H human blood protein.
Store at 4ºC short term, long term store at -80ºC.

Target Information

The H antigen is a precursor to the ABO blood group antigens, present in people of all common blood types.
The Bombay phenotype (hh) does not express antigen H on red blood cells and therefore lacks A or B antigens, similar to the O blood group. However, unlike O group, the H antigen is absent, and individuals produce isoantibodies to antigen H as well as to both A and B antigens.

If they receive blood from someone with O blood group, the anti-H antibodies will bind to the H antigen on donor RBCs and cause complement-mediated lysis.
Therefore, people with Bombay phenotype can receive blood only from other hh donors, although they can donate as though they were type O.

Some individuals with blood group A1 may also produce anti-H antibodies due to complete conversion of H antigen to A1 antigen.
Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19.
The H locus spans more than 5 kb and encodes the fucosyltransferase that produces the H antigen on RBCs.
The H antigen is a carbohydrate sequence linked mainly to protein, with a minor fraction attached to ceramide moiety.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.