Thermo Fisher Scientific alpha-1b Adrenergic Receptor Polyclonal Antibody
Rabbit polyclonal antibody targeting human alpha-1b adrenergic receptor. Validated for WB and IHC applications. Recognizes multiple species based on homology. Supplied as liquid, 0.5 mg/mL in PBS with 0.09% sodium azide. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 270–297 of the central region of human ADRA1B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543911 |
Product Specific Information
This antibody is predicted to react with bovine, mouse, rat, and rabbit based on sequence homology.
Target Information
The alpha-1b adrenoceptor is an adrenergic receptor that mediates smooth muscle contraction, regulating vascular tone and blood pressure, and contributes to the development of atherosclerosis. Decreased expression is associated with benign prostatic hyperplasia (BPH). It can act as a proto-oncogene when constitutively activated, inducing neoplastic transformation. The receptor is expressed in adrenal, aorta, blood, various brain regions, eye, heart, kidney, liver, prostate, spinal cord, and spleen. ESTs have been isolated from kidney (normal and cancer) and lung carcinoma libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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