Thermo Fisher Scientific Bit1 Polyclonal Antibody
Bit1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF에 사용 가능. Human 종 반응성, 항원 친화 크로마토그래피로 정제됨. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PTRH2. Recombinant protein control fragment (Product #RP-90283). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789631 |
Product Specific Information
Immunogen sequence:
KSKTSKTHTD TESEASILGD SGEYKMILVV RNDLKMGKGK VAAQCSHAAV SAYKQIQRRN PEMLKQWEYC GQPKVVVKAP DEETLIALLA HAKMLGLTVS LIQDAGRTQI APGSQTVLGI GPGPADLIDK VTGHLKL
Target Information
The protein encoded by this gene is a mitochondrial protein with two putative domains: an N-terminal mitochondrial localization sequence and a UPF0099 domain.
In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, releasing the peptidyl moiety from tRNA to prevent accumulation of dissociated peptidyl-tRNA that could reduce translation efficiency.
It also plays a role in regulating cell survival and death, promoting survival through integrin-signaling pathways for cells attached to the extracellular matrix.
Mutations are associated with intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency.
Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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