Thermo Fisher Scientific RXRG Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
KDCLIDKRQR NRCQYCRYQK CLVMGMKREA VQEERQRSRE RAESEAECAT SGHEDMPVER ILEAELAVEP KTESYGDMNM ENSTNDPVTN ICHAADKQ

Target Information

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005).
The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors.
RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005).
RAs are known to play key roles in neuronal development, and increasing evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.