Thermo Fisher Scientific UGT1A4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total UGT1A4.

Target Information

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules—such as steroids, bilirubin, hormones, and drugs—into water-soluble, excretable metabolites.
The gene locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini.
Each first exon encodes the substrate binding site and is regulated by its own promoter. This enzyme has some glucuronidase activity toward bilirubin, although it is more active on amines, steroids, and sapogenins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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