Thermo Fisher Scientific TYR Monoclonal Antibody (UMAB257), UltraMAB
TYR 단백질을 인식하는 인간 반응성 마우스 단클론 항체로, Western blot과 IHC(P) 실험에 적합합니다. 동결건조 형태로 제공되며, PBS 및 trehalose 완충액에 보관됩니다. 멜라닌 생합성 관련 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB257 |
| Immunogen | Human recombinant protein fragment (aa 19–320 of human TYR) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The TYR gene encodes an enzyme that catalyzes multiple steps in the conversion of tyrosine to melanin. It exhibits tyrosine hydroxylase and dopa oxidase activities and requires copper for its function. Mutations cause oculocutaneous albinism, while polymorphisms contribute to skin pigmentation variation. The human genome also contains a pseudogene similar to the 3′ half of TYR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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