Thermo Fisher Scientific MORF4 Monoclonal Antibody (OTI1B12), TrueMAB
인간 MORF4 단백질을 표적으로 하는 단클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 고순도 친화 크로마토그래피 정제 제품이며, 핵 내 전사 억제 복합체 연구에 활용 가능합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific MORF4 Monoclonal Antibody (OTI1B12), TrueMAB
Applications and Tested Dilution
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC(P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–255 of human MORF4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cellular senescence is the terminal non-dividing state that normal cells enter following completion of their proliferative potential. Fusions of immortal human cell lines have led to their assignment to one of four complementation groups. Mortality factor 4 (MORF4) was identified as the lead member of a family of transcription factor-like proteins that reverses this immortal phenotype.
Like other members in this family, MORF4 is localized to the nucleus and possesses transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that may allow it to form transcriptionally active homo- or heterodimers. MORF4 binds to transcription corepressors mSin3A and TLE, suggesting that these complexes may play a role in transcriptional repression of genes leading to cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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