Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI3F8), TrueMAB

Applications and Tested Dilutions

Product Specifications

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity but may serve as plasma carrier molecules.

Platelet factor XIII is comprised only of two A subunits, identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme factor XIIIa. This enzyme acts as a transglutaminase to catalyze crosslinking between fibrin molecules, stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin.

Factor XIII deficiency is classified into two categories:

• Type I deficiency: Lack of both A and B subunits
• Type II deficiency: Lack of A subunit alone

These defects can result in lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.