Thermo Fisher Scientific BARD1 Monoclonal Antibody (2A11)
BARD1 단백질을 인식하는 Mouse monoclonal 항체로, Human 시료에 반응합니다. ICC/IF 및 ELISA에 사용 가능하며, Affinity chromatography로 정제되었습니다. PBS(pH 7.4) 용액 형태로 제공되며, -20°C에서 보관합니다.
- 카탈로그번호
- H00000580-M01
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A11 |
| Immunogen | BARD1 (NP_000456, 658–757 a.a.) partial recombinant protein with GST tag. MW of GST tag alone: 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
RRSRLNREQL LPKLFDGCYF YLWGTFKHHP KDNLIKLVTA GGGQILSRKP KPDSDVTQTI NTVAYHARPD SDQRFCTQYI IYEDLCNYHP ERVRQGKVWK
Target Information
This gene encodes a protein that interacts with the N-terminal region of BRCA1. It shares homology with conserved BRCA1 regions, including the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in proteins regulating cell growth, including tumor suppressors and proto-oncogenes. BARD1 also contains three tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic BRCA1 mutations, suggesting that their stable complex formation is crucial for BRCA1 tumor suppression. Mutations in BARD1 may be implicated in breast or ovarian cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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