Thermo Fisher Scientific PDE6 Beta Polyclonal Antibody, Biotin
PDE6 Beta 단백질을 인식하는 Biotin-conjugated Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Bovine, Human, Mouse, Pig, Rat 반응성. Affinity chromatography로 정제된 고품질 항체.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic cyclic peptide common to all PDE6 Beta variants |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The second messengers cAMP and cGMP are key regulatory molecules involved in numerous signal transduction pathways. Their levels are controlled by synthesis through nucleotide cyclases and hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of cyclic nucleotides to their corresponding nucleoside monophosphates.
PDE6 functions as the effector enzyme in the G protein-mediated visual signal transduction cascade. It consists of five subunits: rod and cone-specific catalytic subunits (alpha', alpha, beta), an inhibitory subunit gamma, and a delta subunit of uncertain function. The catalytic core comprises alpha'/alpha' homodimers in cones and alpha/beta heterodimers in rods. Post-translational modifications such as methylation, myristoylation, and prenylation at the C-terminus are essential for proper complex assembly and membrane association.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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