Thermo Fisher Scientific CRTH2 Polyclonal Antibody
CRTH2 (CD294) 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. Western blot 및 ELISA에 사용 가능하며, 고순도 Affinity chromatography로 정제되었습니다. 1 mg/mL 농도의 PBS 용액 형태로 제공되며, 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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- PA123419
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Thermo Fisher Scientific CRTH2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal residues D(329) D S E L G G A G S S R R R R T S S T A(348) of CRTH2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2263540 |
Product Specific Information
PA1-23419 detects CRTH2 in human samples.
Target Information
CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells that acts as a receptor for prostaglandin D2 (PGD2). It mediates chemotaxis of Th2 cells and eosinophils to PGD2, playing a key role in allergic responses.
CRTH2 knockout mice exhibit enhanced eosinophil recruitment and increased IL-5 and IL-3 production, suggesting that CRTH2 restricts eosinophilia and allergic responses.
CRTH2 is selectively expressed in Th2 lineage cells, with two transcripts identified:
- 3.5 kb transcript in thalamus, frontal cortex, pons, hippocampus
- 3.4 kb transcript in fetal liver, leukocytes, thymus
Single nucleotide polymorphisms in the 3′ UTR of the CRTH2 gene have been associated with asthma susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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