Thermo Fisher Scientific SETD7 Monoclonal Antibody (19)
SETD7 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody. Western blot에 적합하며, 인간 단백질에 반응. Protein A로 정제된 액상 형태로 제공되며, 보존제가 포함되지 않음. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 19 |
| Immunogen | Recombinant Human SETD7/SET7/9 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866622 |
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to transcriptional activation.
Also exhibits methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K motif in substrate proteins. Monomethylates Lys-189 of TAF10, increasing its affinity for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and enhancing p53/TP53-mediated transcriptional activation. [UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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