Thermo Fisher Scientific CUEDC2 Monoclonal Antibody (08)
Human CUEDC2 단백질을 인식하는 Mouse monoclonal antibody로 Flow Cytometry에 사용 가능. Protein A로 정제된 액상 형태이며, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
- Flow Cytometry (Flow): Tested dilution 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 08 |
| Immunogen | Recombinant Human CUEDC2 Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866627 |
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation.
CUE domains are present in eukaryotic proteins involved in ubiquitination and protein trafficking pathways, and may be required for ubiquitination of the proteins in which they are found.
CUEDC2 (CUE domain-containing protein 2) was identified through yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation via the ubiquitin-proteasome pathway.
CUEDC2 also decreases the sumoylation of PR and interacts with IKK-alpha and IKK-beta, reducing NF-kappa-B activation by decreasing IKK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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