Thermo Fisher Scientific GRK2 Recombinant Rabbit Monoclonal Antibody (ARC1013)
GRK2 단백질을 인식하는 토끼 단클론 항체로, Western blot, ICC/IF, ELISA에 사용 가능. HEK293 세포에서 발현된 재조합 항체이며, 고순도 Affinity Chromatography 정제. 인간, 생쥐, 랫트 반응성. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1013 |
| Immunogen | Synthetic peptide corresponding to amino acids 590–689 of human GRK2 (P25098) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849417 |
Product Specific Information
Immunogen sequence:
WRGEGEAPQS LLTMEEIQSV EETQIKERKC LLLKIRGGKQ FILQCDSDPE LVQWKKELRD AYREAQQLVQ RVPKMKNKPR SPVVELSKVP LVQRGSANGL
Target Information
ADRBK1 (GRK2) is a serine/threonine kinase that phosphorylates G protein-coupled receptors (GPCRs). GRK2 (83 kDa) is one of six identified GRK family members and is ubiquitously expressed in mammals. Upon ligand binding and G protein activation, GPCRs are phosphorylated by GRKs, leading to receptor internalization regulated by beta-arrestin-1 and activation of the Ras–Raf–ERK1&2 signaling pathway. GRK2 activity is modulated by phosphorylation (PKC, Src, ERK1&2) and protein interactions. ERK-mediated phosphorylation on serine 670 inactivates GRK2, forming a negative feedback loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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