Thermo Fisher Scientific PIEZO1 Recombinant Mouse Monoclonal Antibody (2-10-R-A)
PIEZO1 단백질을 인식하는 생쥐 유래 재조합 단일클론 항체. WB, IHC, ICC에 적합하며 인간, 생쥐, 랫트 반응성. 단백질 A 정제, 1 mg/mL 농도, PBS/BSA/glycerol buffer. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2-10-R-A |
| Immunogen | Recombinant protein within Human Protein FAM38A aa 1275–1540/2521 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3094150 |
Product Specific Information
- Positive control: Recombinant protein lysates, rat brain tissue, mouse hippocampus tissue, mouse brain tissue
- Predicted band size: 287 kDa
- Subcellular Location: Endoplasmic reticulum membrane, Cell membrane
Target Information
Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel that generates currents characterized by a linear current-voltage relationship sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer.
Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER and subsequent stimulation of calpain signaling. In the kidney, Piezo1 may contribute to detection of intraluminal pressure changes and urine flow sensing. It acts as a shear-stress sensor promoting endothelial cell organization and alignment in the direction of blood flow, and is essential for blood vessel formation and vascular structure in both development and adult physiology.
Defects in the PIEZO1 gene are associated with dehydrated hereditary stomatocytosis and lymphedema-related disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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