Thermo Fisher Scientific SNAI1 Monoclonal Antibody (OTI5E12), TrueMAB
SNAI1 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI5E12). Western blot에 최적화되어 있으며, 1:2,000 희석 비율로 사용 가능. EMT 관련 연구 및 종양 전이 메커니즘 분석에 유용. 액상 형태로 제공되며, -20°C에서 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
- Publications: 1 (Miscellaneous PubMed)
Product Specifications
| 항목 | 내용 |
|---|---|
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5E12 |
| Immunogen | Full-length protein expressed in 293T cells transfected with human SNAI1 expression vector |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and is essential for mesoderm and neural crest formation.
SNAI1 plays a key role in tumor invasion by inducing epithelial-mesenchymal transition (EMT) through E-cadherin down-regulation.
In human breast cancer, expression of SNAI1 and/or SNAI2 (Slug) correlates with E-cadherin repression, metastasis, tumor recurrence, and poor prognosis.
Snail 1 protein in the stroma may serve as a potential prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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