ELK Biotechnology VATA rabbit pAb
VATA rabbit pAb는 인간, 마우스, 돼지 시료에 반응하는 폴리클로날 항체로 WB와 ELISA에 적합합니다. 합성 펩타이드로부터 유래된 면역원으로 제작되었으며, 세포질 및 리소좀에 위치한 단백질 검출에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology VATA rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | VATA rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000, ELISA: 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 67 kD |
| Gene ID (Human) | 523 |
| Human Swiss-Prot No. | P38606 |
| Species Reactivity | Human, Mouse, Swine |
| Cellular Localization | Cytoplasm; cytosol; cytoplasmic vesicle (secretory vesicle, clathrin-coated vesicle membrane); peripheral membrane protein; lysosome. Co-localizes with WFS1 in secretory granules of neuroblastoma cell lines. |
Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase–dependent organelle acidification is essential for intracellular processes such as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.
V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain.
- V1 domain: three A and three B subunits, two G subunits, plus C, D, E, F, and H subunits; contains the ATP catalytic site.
- V0 domain: five subunits (a, c, c’, c”, and d).
Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues.
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