Thermo Fisher Scientific Aurora B Recombinant Rabbit Monoclonal Antibody (AURKB, 3121R)
Aurora B 단백질을 인식하는 재조합 토끼 단클론 항체. 사람 시료에 반응하며 IHC(P)에서 1–2 µg/mL로 사용 가능. Protein A/G로 정제된 액상 항체로, 보존제 없이 PBS(pH 7.4)에 용해. -20°C 또는 -80°C 보관 권장.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AURKB, 3121R |
| Immunogen | Recombinant fragment (around aa 89–251) of human Aurora B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Aurora kinases associate with microtubules during chromosome movement and segregation.
AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers.
This complex functions in chromosome alignment and separation, histone modification, and cytokinesis.
The Chromosomal Passenger Complex (CPC) includes three non-enzymatic subunits—INCENP, survivin, and borealin—which determine the activity, localization, stability, and substrate specificity of Aurora B.
Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and Aurora B.
The quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP–AurB complex may modify histone H3.
AurB is overexpressed in several tumors, including primary breast and colon tumor samples. Its expression appears linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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