Thermo Fisher Scientific GATA-3 (Breast and Urothelial Marker) Recombinant Rabbit Monoclonal Antibody (GATA3/8327R)
GATA-3 단백질을 인식하는 재조합 토끼 단클론 항체로, 유방암 및 요로상피암 표지 연구에 사용됩니다. 인간 시료에 반응하며, IHC(P) 및 IHC(PFA) 실험에 적합합니다. 단백질 A/G 정제, 보존제 무첨가, 액상 형태로 제공됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | GATA3/8327R |
| Immunogen | Recombinant full-length human GATA-3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins.
Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3 is an enhancer-binding protein containing a zinc finger domain and is abundantly expressed in the T-lymphocyte lineage, where it participates in T-cell receptor gene activation.
The human gene comprises six exons distributed over 17 kb of DNA, encoding two zinc fingers conserved with those of GATA1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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