Thermo Fisher Scientific Phospho-GAB2 (Tyr452) Polyclonal Antibody
Phospho-GAB2 (Tyr452) 단백질을 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human GAB2 around the phosphorylation site of Tyr452 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The GAB2 gene belongs to the GRB2-associated binding protein (GAB) family. These proteins contain pleckstrin homology (PH) domains and interact with SHP2 tyrosine phosphatase and GRB2 adapter proteins. They function as adapters for transmitting signals in response to cytokine and growth factor receptor activation, as well as T- and B-cell antigen receptor stimulation. GAB2 is the principal activator of phosphatidylinositol-3 kinase upon high-affinity IgE receptor activation. Two alternatively spliced transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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