Thermo Fisher Scientific Human LGP2 Synthetic Peptide

Thermo Fisher Scientific Human LGP2 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the amino terminus of human LGP2.
PEP-0551 can be used as a blocking peptide with polyclonal antibody PA5-20434.

Target Information

Anti-viral innate immune responses are triggered by pathogen-associated molecular patterns (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms.

The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5, are members of a CARD-helicase family and are expressed in the cytoplasm.

A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.

Usage Notes

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.