Thermo Fisher Scientific Human CDNF Synthetic Peptide
인간 CDNF 단백질의 아미노 말단 12개 아미노산 서열에 해당하는 합성 펩타이드. 폴리클로날 항체 PA5-20430과 함께 차단 펩타이드로 사용 가능. 도파민성 신경세포 연구 및 파킨슨병 모델 연구에 유용. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 12 amino acids near the amino terminus of human CDNF.
PEP-0547 can be used as a blocking peptide with polyclonal antibody PA5-20430.
Target Information
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and is highly homologous to the mesencephalic astrocyte-derived neurotrophic factor (MANF).
CDNF is expressed at higher levels in tissues such as heart, skeletal muscle, and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease. Furthermore, CDNF was able to restore dopaminergic function and prevent degeneration of dopaminergic neurons in the substantia nigra, suggesting potential therapeutic use for Parkinson’s disease.
At least two isoforms of CDNF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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