Thermo Fisher Scientific DFNA5 Polyclonal Antibody

Thermo Fisher Scientific DFNA5 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:300–1:2,000
• Immunohistochemistry (IHC): 1:300–1:2,000

Product Specifications

Product Specific Information

Reconstitute with 100 µL of distilled water.

Target Information

DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein expressed in cochlea, placenta, brain, heart, liver, lung, and pancreas. It exists as two alternatively spliced isoforms (short and long).
Defects in the DFNA5 gene cause non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of hearing loss due to damage in brain structures that process sound.
The DFNA5 gene is located on human chromosome 7, which contains over 1,000 genes (~5% of the genome). Mutations in genes on chromosome 7 have been associated with Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.