Thermo Fisher Scientific CARF Polyclonal Antibody
Human CARF 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, 0.3 mg/mL 농도의 액상 형태. p53 경로 관련 연구 및 세포 사멸 신호전달 연구에 활용 가능. 연구용 한정.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CARF. Recombinant protein control fragment (Product # RP-108359) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790799 |
Product Specific Information
Immunogen sequence:
NNSLLLGQSH SLQRDTCLTQ NNSTASTMGN LPEPDQNLVA MDELVEVGDV EDTGNLEGTV HRILLGDVQT IPIQIIDNHS ALIEENPEST ISVSQV
Target Information
CARF (Calcium-Response Factor)
Also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, CARF is a 725 amino acid nuclear protein expressed in a wide variety of tissues, with highest expression in the hippocampus. It is thought to function as a transcription factor associated with the p53 tumor suppression pathway.
CARF cooperates and co-localizes with ARF (ADP-ribosylation factor) and helps mediate ARF-p53-induced apoptotic signaling. This pathway is involved in cell cycle control, cellular development, DNA damage response, and aging processes, suggesting CARF plays roles in multiple cellular events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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