Thermo Fisher Scientific ASXL1 Polyclonal Antibody
ASXL1 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 및 생쥐 시료에 반응합니다. Western blot과 IHC(P) 등에 사용 가능하며, 고순도의 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 단기 4°C, 장기 -20°C 보관을 권장합니다.
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Thermo Fisher Scientific ASXL1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human ASXL1. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735488 |
Product Specific Information
- Positive Control: human ASXL1-transfected 293T cells
- Predicted Reactivity: Mouse (93%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG).
Acts as coactivator of RARA and RXRA through association with NCOA1.
Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters.
Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity.
Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at Lys-119 (H2AK119ub1).
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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