Thermo Fisher Scientific TET2 Polyclonal Antibody
TET2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, IP 등 다양한 응용에 사용 가능. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C에서 보관. DNA 탈메틸화 연구에 적합한 고품질 항체.
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Applications and Tested Dilutions
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 100 and 150 of Human Tet Oncogene Family Member 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Target Information
TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation.
TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs and mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and 5fC to 5-carboxylcytosine (5caC).
These conversions likely represent the first steps in cytosine demethylation.
In addition to its role in DNA demethylation, TET2 recruits O-GlcNAc transferase (OGT) to CpG-rich transcription start sites of active genes, promoting histone H2B GlcNAcylation.
Mutations in the TET2 gene are associated with Polycythemia vera and Myelodysplastic syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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