Thermo Fisher Scientific PAX8 Recombinant Rabbit Monoclonal Antibody (PAX8, 2774R)
PAX8 단백질을 인식하는 재조합 토끼 단클론 항체로, IHC(P) 실험에 적합합니다. Dog 및 Human 시료 반응성이 있으며, 고순도 Protein A/G 정제 방식으로 제조되었습니다. 무보존제 PBS 용액 형태로 제공되며, -20°C 이하에서 보관합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PAX8, 2774R |
| Immunogen | Recombinant fragment (around aa 60–261) of human PAX8 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature (RT).
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at RT for 20 min.
Target Information
The PAX8 gene encodes a member of the paired box family of transcription factors. These proteins contain a paired box domain, an octapeptide, and a paired-type homeodomain.
This nuclear protein is involved in thyroid follicular cell development and regulation of thyroid-specific gene expression.
Mutations in PAX8 are associated with thyroid dysgenesis, follicular carcinomas, and atypical follicular thyroid adenomas.
Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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