Thermo Fisher Scientific IL-29 Monoclonal Antibody (09)

Applications

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human IL-29.

Target Information

IFN-lambdas constitute a novel family of interferons that mediate the induction of antiviral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known as IL-29, IL-28A, and IL-28B, respectively.
Similar to type I IFNs, IFN-lambdas activate intracellular signaling to promote gene expression. They mediate antiviral protection through a class II cytokine receptor complex composed of CRF2-12/IFN-lambdaR1 (unique to IFN-lambdas) and CFR2-4/IL-10R2 (shared with IL-10, IL-22, and IL-26 receptors).
IL-28 and IL-29 have been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. Dendritic cells differentiated in response to IFN-lambdas express high levels of class I and II MHC gene products but low levels of costimulatory molecules. These cells can specifically induce IL-2-dependent proliferation of CD4⁺CD25⁺FOXP3⁺ T cells with contact-dependent suppressive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.